What is Tysabri?

Tysabri is a monoclonal antibody that affects the actions of the body's immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Tysabri is used to treat relapsing forms of multiple sclerosis.

Tysabri is also used to treat moderate to severe Crohn's disease in adults. It is usually given after other Crohn's disease medications have been tried without successful treatment of this condition.

What you may expect at your TYSABRI infusion each month

Before every TYSABRI infusion therapy, you will receive a copy of the Patient Medication Guide to review. Then you will be asked the following questions to confirm that TYSABRI is still right for you. You will need to answer whether you:

• Have any new or worsening medical problems
• Have a condition or are taking medicines that could weaken your immune system
• Have taken steroid medicines

Depending on your answers, the technician will either give you your infusion or contact your doctor for further instructions.

The infusion itself will take approximately 1 hour. After the infusion therapy, you will be observed for another hour to make sure you are not having any reactions that may need medical help.

What you should tell your doctor and nurse before receiving each infusion of TYSABRI

Tell your doctor and nurse about all of your medical conditions. Tell them if you:

• Have any new or worsening medical problems (such as a new or sudden change in your thinking, eyesight, balance, or strength or other problems) that have lasted several days
• Have had hives, itching, or trouble breathing during or after an infusion of TYSABRI
• Have a fever or infection (including shingles or any unusually long-lasting infection)
• Are pregnant or plan to become pregnant
• Are breastfeeding

Tell your doctor and nurse about all of the medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements. It may be helpful to keep a list of these medications and bring it with you to every appointment.